Non-carbohydrate inhibitors of the lectin DC-SIGN.

@article{Borrok2007NoncarbohydrateIO,
  title={Non-carbohydrate inhibitors of the lectin DC-SIGN.},
  author={M. Jack Borrok and Laura L Kiessling},
  journal={Journal of the American Chemical Society},
  year={2007},
  volume={129 42},
  pages={
          12780-5
        }
}
The C-type lectin dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) is found on the surface of dendritic cells. It can mediate adhesion between dendritic cells and T lymphocytes and facilitate antigen capture and presentation. Many pathogens can exploit DC-SIGN binding for nefarious purposes. For example, DC-SIGN can facilitate the dissemination of viruses, like HIV-1. Alternatively, some microbes (e.g., Mycobacterium tuberculosis) use their ability to… CONTINUE READING

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