Non-canonical uracil processing in DNA gives rise to double-strand breaks and deletions: relevance to class switch recombination

@inproceedings{Bregenhorn2016NoncanonicalUP,
  title={Non-canonical uracil processing in DNA gives rise to double-strand breaks and deletions: relevance to class switch recombination},
  author={Stephanie Bregenhorn and Lia Kallenberger and Mariela Artola-Bor{\'a}n and Javier Pe{\~n}a-Diaz and Josef Jiricny},
  booktitle={Nucleic acids research},
  year={2016}
}
During class switch recombination (CSR), antigen-stimulated B-cells rearrange their immunoglobulin constant heavy chain (CH) loci to generate antibodies with different effector functions. CSR is initiated by activation-induced deaminase (AID), which converts cytosines in switch (S) regions, repetitive sequences flanking the CH loci, to uracils. Although U/G mispairs arising in this way are generally efficiently repaired to C/Gs by uracil DNA glycosylase (UNG)-initiated base excision repair (BER… CONTINUE READING

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