Non-canonical translation start sites in the TMEM16A chloride channel☆

  title={Non-canonical translation start sites in the TMEM16A chloride channel☆},
  author={Elvira Sondo and Paolo Scudieri and Valeria Tomati and Emanuela Caci and Amelia Mazzone and Gianrico Farrugia and Roberto Ravazzolo and Luis J. V. Galietta},
  booktitle={Biochimica et biophysica acta},
TMEM16A is a plasma membrane protein with voltage- and calcium-dependent chloride channel activity. The role of the various TMEM16A domains in expression and function is poorly known. In a previous study, we found that replacing the first ATG of the TMEM16A coding sequence with a nonsense codon (M1X mutation), to force translation from the second ATG localized at position 117, only had minor functional consequences. Therefore, we concluded that this region is dispensable for TMEM16A processing… CONTINUE READING


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