Non-canonical roles of PFKFB3 in regulation of cell cycle through binding to CDK4

Abstract

There is growing interest in studying the molecular mechanisms of crosstalk between cancer metabolism and the cell cycle. 6-phosphate fructose-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) is a well-known glycolytic activator that plays an important role in tumorigenesis. We investigated whether PFKFB3 was directly involved in oncogenic signaling networks… (More)
DOI: 10.1038/s41388-017-0072-4

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