Non-canonical features of the Golgi apparatus in bipolar epithelial neural stem cells

@article{Taverna2016NoncanonicalFO,
  title={Non-canonical features of the Golgi apparatus in bipolar epithelial neural stem cells},
  author={Elena Taverna and Felipe Mora-Berm{\'u}dez and Paulina J Strzyz and Marta Florio and Jaroslav Icha and Christiane Haffner and Caren Norden and Michaela Wilsch-Br{\"a}uninger and Wieland B. Huttner},
  journal={Scientific Reports},
  year={2016},
  volume={6}
}
Apical radial glia (aRG), the stem cells in developing neocortex, are unique bipolar epithelial cells, extending an apical process to the ventricle and a basal process to the basal lamina. Here, we report novel features of the Golgi apparatus, a central organelle for cell polarity, in mouse aRGs. The Golgi was confined to the apical process but not associated with apical centrosome(s). In contrast, in aRG-derived, delaminating basal progenitors that lose apical polarity, the Golgi became… 
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References

SHOWING 1-10 OF 85 REFERENCES
Dual Modes of Endoplasmic Reticulum-to-Golgi Transport in Dendrites Revealed by Live-Cell Imaging
TLDR
It is demonstrated that two organizations of the secretory pathway exist in neurons: one requiring processing of membrane and lipids in the Golgi complex of the cell body and one in which endoplasmic reticulum (ER)-to-Golgi trafficking is localized to dendrites.
Golgi apparatus partitioning during cell division (Review)
TLDR
It is suggested that in mammalian cells this organelle remains distinct during mitosis, although highly fragmented through the formation of mitotic Golgi clusters of small tubules and vesicles, and that at the onset of mitosis the Golgi apparatus completely loses its identity and is reabsorbed into the endoplasmic reticulum.
Live Imaging at the Onset of Cortical Neurogenesis Reveals Differential Appearance of the Neuronal Phenotype in Apical versus Basal Progenitor Progeny
TLDR
The observations imply that the loss of apical-basal polarity restricts neuronal progenitors to the symmetric mode of cell division, and that basal progenitor-derived neurons initiate the expression of neuronal phenotype already before mitosis, in contrast to apical prognitors.
Golgi apparatus partitioning during cell division.
TLDR
It is suggested that in mammalian cells this organelle remains distinct during mitosis, although highly fragmented through the formation of mitotic Golgi clusters of small tubules and vesicles, and that at the onset of mitosis the Golgi apparatus completely loses its identity and is reabsorbed into the endoplasmic reticulum.
Myosin II is required for interkinetic nuclear migration of neural progenitors
TLDR
The data suggest a unifying concept in which the actomyosin contraction underlying ab-centrosomal INM sets the stage for the evolutionary increase in VZ pseudostratification and for SVZ progenitor delamination, a key process in cortical expansion.
Partitioning of the Golgi Apparatus during Mitosis in Living HeLa Cells
TLDR
The results provide direct evidence for mitotic clusters as the unit of partitioning and suggest that precise regulation of the number, position, and compartmentation of mitotic membranes is a critical feature for the ordered inheritance of the Golgi apparatus.
The subcellular organization of Madin-Darby canine kidney cells during the formation of a polarized epithelium
TLDR
Findings show that there is an extensive remodeling of epithelial cytoarchitecture after formation of cell-cell contacts, which results in functional polarization of the cytoplasm.
...
...