Non-canonical Notch signaling: emerging role and mechanism.


Notch is an ancient transmembrane receptor with crucial roles in cell-fate choices. Although the 'canonical' Notch pathway and its core members are well established - involving ligand-induced cleavage of Notch for transcriptional regulation - it has been unclear whether Notch can also function independently of ligand and transcription ('non-canonically') through a common mechanism. Recent studies suggest that Notch can non-canonically exert its biological functions by post-translationally targeting Wnt/β-catenin signaling, an important cellular and developmental regulator. The non-canonical Notch pathway appears to be highly conserved from flies to mammals. Here, we discuss the emerging conserved mechanism and role of ligand/transcription-independent Notch signaling in cell and developmental biology.

DOI: 10.1016/j.tcb.2012.02.003
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@article{Andersen2012NoncanonicalNS, title={Non-canonical Notch signaling: emerging role and mechanism.}, author={Peter Andersen and Hideki Uosaki and Lincoln Takura Shenje and Chulan Kwon}, journal={Trends in cell biology}, year={2012}, volume={22 5}, pages={257-65} }