Non-bronchoscopic sampling and culture of bronchial epithelial cells in children.

  title={Non-bronchoscopic sampling and culture of bronchial epithelial cells in children.},
  author={Gary M Doherty and Sharon N Christie and Grzegorz Skibinski and Sarah M. Puddicombe and Timothy J Warke and Francine de Courcey and Andrew L Cross and Jeremy David Morrell Lyons and Madeleine Ennis and Michael D. Shields and Liam G Heaney},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  volume={33 9},
BACKGROUND The bronchial epithelium is likely to play a vital role in airway diseases in children, such as asthma and viral-associated wheeze. In adults, studies with primary bronchial epithelial cells cultured from samples obtained by fibre-optic bronchoscopy have provided key insights into the role of the epithelial cell. However, it is difficult to justify bronchoscopy in children to obtain epithelial cells for research purposes. OBJECTIVE To examine the possibility of retrieving and… CONTINUE READING


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