Non-bronchodilating mechanisms of tiotropium prevent airway hyperreactivity in a guinea-pig model of allergic asthma.

@article{Buels2012NonbronchodilatingMO,
  title={Non-bronchodilating mechanisms of tiotropium prevent airway hyperreactivity in a guinea-pig model of allergic asthma.},
  author={Kalmia S Buels and David B Jacoby and Allison D Fryer},
  journal={British journal of pharmacology},
  year={2012},
  volume={165 5},
  pages={1501-14}
}
BACKGROUND AND PURPOSE Asthma is characterized by reversible bronchoconstriction and airway hyperreactivity. Although M(3) muscarinic receptors mediate bronchoconstriction, non-selective muscarinic receptor antagonists are not currently recommended for chronic control of asthma. We tested whether selective blockade of M(3) receptors, at the time of antigen challenge, blocks subsequent development of airway hyperreactivity in antigen-challenged guinea-pigs. EXPERIMENTAL APPROACH Ovalbumin… CONTINUE READING

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