Non-apoptotic signaling pathways activated by soluble Fas ligand in serum-starved human fibroblasts. Mitogen-activated protein kinases and NF-kappaB-dependent gene expression.

@article{Ahn2001NonapoptoticSP,
  title={Non-apoptotic signaling pathways activated by soluble Fas ligand in serum-starved human fibroblasts. Mitogen-activated protein kinases and NF-kappaB-dependent gene expression.},
  author={Jung Hyuk Ahn and Suk Min Park and Hyung Suck. Cho and Myeung Su Lee and Jong Bok Yoon and Jan Vil{\vc}ek and Thomas Hun-Tak Lee},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 50},
  pages={
          47100-6
        }
}
Many Fas-expressing cells do not undergo cell death upon Fas stimulation. In the normal human diploid cell line GM6112, the addition of soluble Fas ligand (sFasL) leads to morphological signs of cell death in less than 1% of cells. Treatment of serum-starved GM6112 fibroblasts with sFasL resulted in a rapid and transient phosphorylation of ERK1/2 without a significant increase in JNK and p38 activities. Unless co-treated with the protein synthesis inhibitor anisomycin, sFasL did not show gene… CONTINUE READING

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