Non-apoptotic routes to defeat cancer.

Abstract

The mechanism of tumor cell death after treatment with DNA alkylating agents in vivo previously remained largely unknown. We demonstrate that tumor regression after chemotherapy occurs via sporadic necrosis and relies on activation of innate immunity in a manner dependent on high mobility group box 1 protein (HMGB1).

Cite this paper

@article{Guerriero2012NonapoptoticRT, title={Non-apoptotic routes to defeat cancer.}, author={Jennifer L. Guerriero and Dara Ditsworth and Wei-Xing Zong}, journal={Oncoimmunology}, year={2012}, volume={1 1}, pages={94-96} }