Non-apoptotic Fas signaling.

  title={Non-apoptotic Fas signaling.},
  author={Harald Wajant and Klaus Pfizenmaier and Peter Scheurich},
  journal={Cytokine & growth factor reviews},
  volume={14 1},
Fas (Apo-1, CD95) and Fas-Ligand (FasL, CD95L) are typical members of the TNF receptor and TNF ligand family, respectively, with a pivotal role in the regulation of apoptotic processes, including activation-induced cell death, T-cell-induced cytotoxicity, immune privilege and tumor surveillance. Impairment of the FasL/Fas system has been implicated in liver failure, autoimmune diseases and immune deficiency. Thus, the FasL/Fas system was mainly appreciated with respect to its death-inducing… CONTINUE READING


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