Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology.

@article{Gordon2015NonanimalMO,
  title={Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology.},
  author={Sarah Gordon and Mardas Daneshian and Joke A. Bouwstra and Francesca Caloni and Samuel Constant and Donna E Davies and Gudrun Dandekar and Carlos Alberto Chavez Guzm{\'a}n and Eric Fabian and Eleonore Haltner and Thomas Hartung and Nina Hasiwa and Patrick J. Hayden and Helena Kanď{\'a}rov{\'a} and Sangeeta Khare and Harald F Krug and Carsten Kneuer and Marcel Leist and Guoping Lian and Uwe Marx and Marco Metzger and Katharina Ott and Pilar Prieto and Michael S. Roberts and Erwing Ludo Roggen and Tewes Tralau and Claudia C M van den Braak and Heike Walles and Claus-Michael Lehr},
  journal={ALTEX},
  year={2015},
  volume={32 4},
  pages={
          327-78
        }
}
Models of the outer epithelia of the human body - namely the skin, the intestine and the lung - have found valid applications in both research and industrial settings as attractive alternatives to animal testing. A variety of approaches to model these barriers are currently employed in such fields, ranging from the utilization of ex vivo tissue to reconstructed in vitro models, and further to chip-based technologies, synthetic membrane systems and, of increasing current interest, in silico… CONTINUE READING

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