Non-anaphylactic surface-exposed peptides of the major birch pollen allergen, Bet v 1, for preventive vaccination.

@article{Focke2004NonanaphylacticSP,
  title={Non-anaphylactic surface-exposed peptides of the major birch pollen allergen, Bet v 1, for preventive vaccination.},
  author={Margarete Focke and Birgit Linhart and Arnulf Hartl and Ursula Wiedermann and Wolfgang R Sperr and Peter Valent and Josef Thalhamer and Dietrich Kraft and Rudolf Valenta},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={2004},
  volume={34 10},
  pages={1525-33}
}
BACKGROUND Almost 100 million allergic patients are sensitized to the major birch pollen allergen, Bet v 1, a 17 kDa protein containing most of the IgE epitopes present in pollens of trees belonging to the Fagales order and plant-derived food. OBJECTIVE Our aim was to develop an approach for the rational design of B cell epitope-derived, non-allergenic peptide allergy vaccines. METHODS According to the three-dimensional (3-D) structure of birch pollen allergen, Bet v 1, six peptides… CONTINUE READING
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