Non-amidated forms of VIP (glycine-extended VIP and VIP-free acid) have full bioactivity on smooth muscle.

@article{Fahrenkrug1989NonamidatedFO,
  title={Non-amidated forms of VIP (glycine-extended VIP and VIP-free acid) have full bioactivity on smooth muscle.},
  author={Jan Fahrenkrug and B. V. Ottesen and Connie Palle},
  journal={Regulatory peptides},
  year={1989},
  volume={26 3},
  pages={235-9}
}
The aim of the present study was to elucidate the importance of the C-terminal amide group for the biological activity of vasoactive intestinal peptide (VIP). Two synthetic peptides lacking the amide group: VIP having a carboxyl group at the C-terminus and the intermediate biosynthetic precursor, glycine-extended VIP were compared with VIP itself regarding the ability to inhibit spontaneous activity in smooth muscle strips from rat stomach and human Fallopian tube. Both the glycine-extended VIP… CONTINUE READING

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