Non-alcoholic fatty liver disease: an emerging pathological spectrum

@article{Zafrani2003NonalcoholicFL,
  title={Non-alcoholic fatty liver disease: an emerging pathological spectrum},
  author={Elie Serge Zafrani},
  journal={Virchows Archiv},
  year={2003},
  volume={444},
  pages={3-12}
}
The spectrum of pathological lesions observed in non-alcoholic fatty liver disease (NAFLD) is wide and strongly resembles that of alcohol-induced liver disease. It ranges from fatty liver to steatohepatitis, progressive fibrosis and cirrhosis. Hepatocellular carcinoma is a possible complication of NAFLD, but whether it is related to frequently associated metabolic disorders (e.g., overweight, diabetes) or to underlying cirrhosis is unclear. This disease is the result of a multi-factorial… 
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116 Citations

Nonalcoholic fatty liver disease . A pathological spectrum -

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Nonalcoholic fatty liver disease is a complex multifactorial process in which the genetic environment has considerable importance, since it is still unknown why some patients have only steatosis while others develop steatohepatitis, cirrhosis or hepatocellular carcinoma.

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PPARa in the Pathogenesis of Fatty liver Disease

  • Medicine
  • 2005
atty liver disease (FLD), which is emerging as the most common liver disease in clinical practice, is F etiologically diverse and encompasses a morphological spectrum consisting of hepatic steatosis…

Does nonalcoholic fatty liver disease predispose patients to hepatocellular carcinoma in the absence of cirrhosis?

The cases presented here suggest that NAFLD may predispose patients to HCC in the absence of cirrhosis, and further studies are needed to confirm this potentially important observation.

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  • J. ReddyM. Rao
  • Medicine
    American journal of physiology. Gastrointestinal and liver physiology
  • 2006
The indistinguishable spectrum of histological features of both AFLD and NAFLD suggests a possible convergence of pathogenetic mechanisms at some critical juncture that enables the progression of steatohepatitis toward cirrhosis and liver cancer.

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Several biomarker candidates in the phosphatidylcholine fraction for which a 36:1 PCh could accounted as a clear biomarker for HCC are found in this C57bl6 mouse model, highlighting new biochemical insights on molecular mechanisms underlying liver cancer disease.

Review article: is non‐alcoholic fatty liver disease a spectrum, or are steatosis and non‐alcoholic steatohepatitis distinct conditions?

  • Y. Yılmaz
  • Medicine
    Alimentary pharmacology & therapeutics
  • 2012
Non‐alcoholic fatty liver disease (NAFLD) is currently conceptualised as a clinical spectrum that results from a ‘multiple‐hit’ process which begins with simple steatosis and subsequently renders the…

[Non-alcoholic fatty liver disease].

Hepatic steatosis and fibrosis in chronic hepatitis C in Taiwan.

Hepatic steatosis was associated with being overweight, hepatic fibrosis, and triglyceride level in chronic hepatitis C, and according to multivariate analysis, BMI is the strongest risk factor associated with hepatic Steatosis.
...

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