Non-adrenergic, non-cholinergic nervous system and overnight airway calibre in asthmatic and normal subjects.

@article{Mackay1991NonadrenergicNN,
  title={Non-adrenergic, non-cholinergic nervous system and overnight airway calibre in asthmatic and normal subjects.},
  author={Thomas W. Mackay and Michael F. Fitzpatrick and Neil J. Douglas},
  journal={Lancet},
  year={1991},
  volume={338 8778},
  pages={1289-92}
}
Increased parasympathetic tone does not fully explain the night-time bronchoconstriction responsible for nocturnal cough and wheezing in asthmatic subjects. The overnight variation in function of the other neural pathway innervating bronchial smooth muscle--the non-adrenergic, non-cholinergic (NANC) system--was thus examined. NANC function was tested after parasympathetic and beta-adrenergic blockade in 12 normal subjects and 12 patients with mild asthma by comparing the bronchodilator effect… CONTINUE READING