Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans.

@article{Broglio2004NonacylatedGC,
  title={Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans.},
  author={Fabio Broglio and Cristina Gottero and Flavia Prodam and Carlotta Gauna and G. Muccioli and Mauro Papotti and Thierry Abribat and Aart J van der Lely and Ezio Ghigo},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2004},
  volume={89 6},
  pages={3062-5}
}
Ghrelin possesses strong GH-releasing activity but also other endocrine activities including stimulation of PRL and ACTH secretion, modulation of insulin secretion and glucose metabolism. It is assumed that the GH secretagogue (GHS) receptor (GHS-R) 1a mediates ghrelin actins provided its acylation in Serine 3; in fact, acylated ghrelin only is able to exert endocrine activities. Acylated ghrelin (AG) is present in serum at a 2.5 fold lower concentration than unacylated ghrelin (UAG). UAG… CONTINUE READING
128 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 128 extracted citations

Similar Papers

Loading similar papers…