Non-activated plasma-derived PC improves amputation rate of children undergoing sepsis.

@article{Piccin2014NonactivatedPP,
  title={Non-activated plasma-derived PC improves amputation rate of children undergoing sepsis.},
  author={Andrea Piccin and Aengus O' Marcaigh and Corrina Mc Mahon and Ciaran Murphy and Ikechukwu Okafor and Luigi Marcheselli and William Casey and Liam Claffey and Owen Patrick Smith},
  journal={Thrombosis research},
  year={2014},
  volume={134 1},
  pages={63-7}
}
Low circulating protein C (PC) levels have been observed in sepsis, especially in patients with Neisseriae Meningitides infections. Poor clinical outcome and high limb amputation rates have been associated in infected patients with low circulating PC levels. Published studies using activated PC replacement therapy patients with sepsis have shown reduced mortality rates, however, its use has been associated with severe bleeding events. Paediatric sepsis studies using non-activated plasma-derived… CONTINUE READING