Non-Synonymous Polymorphisms in the FCN1 Gene Determine Ligand-Binding Ability and Serum Levels of M-Ficolin

@inproceedings{Ammitzbll2012NonSynonymousPI,
  title={Non-Synonymous Polymorphisms in the FCN1 Gene Determine Ligand-Binding Ability and Serum Levels of M-Ficolin},
  author={Christian Gytz Ammitzb\oll and Troels R\onn Kj{\ae}r and Rudi M Steffensen and Kristian Stengaard-Pedersen and Hans J\orgen Nielsen and Steffen Thiel and Martin B\ogsted and Jens Christian Jensenius},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND The innate immune system encompasses various recognition molecules able to sense both exogenous and endogenous danger signals arising from pathogens or damaged host cells. One such pattern-recognition molecule is M-ficolin, which is capable of activating the complement system through the lectin pathway. The lectin pathway is multifaceted with activities spanning from complement activation to coagulation, autoimmunity, ischemia-reperfusion injury and embryogenesis. Our aim was to… CONTINUE READING

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