Non-NMDA receptor-mediated neurotoxicity in cortical culture.

  title={Non-NMDA receptor-mediated neurotoxicity in cortical culture.},
  author={Jae Young Koh and Mark P. Goldberg and David M. Hartley and Dennis W. Choi},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={10 2},
The neurotoxicity of 3 non-NMDA glutamate receptor agonists--kainate, alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA), and quisqualate--was investigated quantitatively in dissociated murine cortical cultures. Five minute exposure to 500 microM kainate, but not AMPA, produced widespread acute neuronal swelling. Kainate-induced swelling was resistant to 2-amino-5-phosphonovalerate (APV) or replacement of extracellular sodium with choline but attenuated by either kynurenate or low… CONTINUE READING
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