Non-Mendelian determinant [ISP+] in yeast is a nuclear-residing prion form of the global transcriptional regulator Sfp1.

@article{Rogoza2010NonMendelianD,
  title={Non-Mendelian determinant [ISP+] in yeast is a nuclear-residing prion form of the global transcriptional regulator Sfp1.},
  author={Tatyana Rogoza and Alexander Goginashvili and Sofia Rodionova and Maxim A Ivanov and Olga V. Viktorovskaya and Alexander Rubel and Kirill V Volkov and Ludmila N Mironova},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 23},
  pages={10573-7}
}
Four protein-based genetic determinants or prions-[SWI(+)], [MCA], [OCT(+)], and [MOT3(+)]-are recent additions to the list of well-known Saccharomyces cerevisiae prions, [PSI(+)], [URE3], and [PIN(+)]. A rapid expansion of this list may indicate that many yeast proteins can convert into heritable prion forms and underscores a problem of prion input into cellular physiology. Here, we prove that the global transcriptional regulator Sfp1 can become a prion corresponding to the prion-like… CONTINUE READING