Non-Immunologic Actions of Calcineurin Inhibitors in Proteinuric Kidney Diseases

  title={Non-Immunologic Actions of Calcineurin Inhibitors in Proteinuric Kidney Diseases},
  author={Robert F Spurney},
  booktitle={Front. Endocrinol.},
Diseases affecting the glomerulus are the most common cause of end-stage kidney disease in developed countries (1). These disorders are characterized by significant proteinuria, and the level of proteinuria is an independent risk factor for disease progression (2). Podocytes are thought to play a key role in the pathogenesis of glomerular diseases (3, 4). The importance of podocytes in glomerular diseases is highlighted by genetic studies, which have identified mutant podocyte proteins that… CONTINUE READING
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2014 update

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  • 2014
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