Non-Hodgkin's lymphoma in Job's syndrome: a case report and literature review.

  title={Non-Hodgkin's lymphoma in Job's syndrome: a case report and literature review.},
  author={Gregory D. Leonard and Edwin M. Posadas and Paul C. Herrmann and Victoria L. Anderson and Elaine S. Jaffe and Steven M Holland and Wyndham H. Wilson},
  journal={Leukemia & lymphoma},
  volume={45 12},
Job's or hyper immunoglobulin E recurrent infection syndrome (Hyper-IgE syndrome) is a rare, often inherited multisystem disorder, characterized by cutaneous abscesses, pneumonia, elevated IgE levels and skeletal defects. We report a case of a 22-year-old man with Job's syndrome who presented with back pain. He was found to have diffuse large B-cell lymphoma involving his second lumbar vertebrae and spleen. Treatment with dose-adjusted EPOCH-rituximab (DA-EPOCH-R) chemotherapy achieved a… CONTINUE READING
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