Non-Hebbian properties of long-term potentiation enable high-capacity encoding of temporal sequences.

@article{Granger1994NonHebbianPO,
  title={Non-Hebbian properties of long-term potentiation enable high-capacity encoding of temporal sequences.},
  author={Richard Granger and James Whitson and John Larson and Gary Lynch},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 21},
  pages={10104-8}
}
A hypothesis commonly found in biological and computational studies of synaptic plasticity embodies a version of the 1949 postulate of Hebb that coactivity of pre- and postsynaptic elements results in increased efficacy of their synaptic contacts. This general proposal presaged the identification of the first and still only known long-lasting synaptic plasticity mechanism, long-term potentiation (LTP). Yet the detailed physiology of LTP induction and expression differs in many specifics from… CONTINUE READING