Non-HLA antibodies: angiotensin II type 1 receptor (anti-AT1R) and endothelin-1 type A receptor (anti-ETAR) are associated with renal allograft injury and graft loss.

@article{Banasik2014NonHLAAA,
  title={Non-HLA antibodies: angiotensin II type 1 receptor (anti-AT1R) and endothelin-1 type A receptor (anti-ETAR) are associated with renal allograft injury and graft loss.},
  author={Mirosław Banasik and Maria Boratyńska and Katarzyna Kościelska-Kasprzak and Dorota Kamińska and Slawomir C. Zmonarski and Oktawia Mazanowska and Magdalena Krajewska and Dorota Bartoszek and Marcelina Żabińska and Marta Myszka and Małgorzata Kamińska and Agnieszka Hałoń and Tomasz Dawiskiba and Przemysław Szyber and Attila Sas and Marian Klinger},
  journal={Transplantation proceedings},
  year={2014},
  volume={46 8},
  pages={2618-21}
}
INTRODUCTION Non-HLA antibodies specific for angiotensin II type 1 receptor (anti-AT1R) and endothelin-1 type A receptor (anti-ETAR) of vascular cells activate signaling pathways leading to cell proliferation and vascular injury. The aim of this study was to evaluate the impact of non-HLA antibodies on kidney allograft morphology and function in patients who underwent a kidney biopsy due to renal function impairment. PATIENTS AND METHODS The study included 65 consecutive renal transplant… CONTINUE READING

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