Non-Fc receptor-binding humanized anti-CD3 antibodies induce apoptosis of activated human T cells.

@article{Carpenter2000NonFcRH,
  title={Non-Fc receptor-binding humanized anti-CD3 antibodies induce apoptosis of activated human T cells.},
  author={Paul A Carpenter and Sanja Pavlovic and J. Yun Tso and Oliver W Press and Theodore A Gooley and Xuesong Yu and Claudio Anasetti},
  journal={Journal of immunology},
  year={2000},
  volume={165 11},
  pages={6205-13}
}
Human trials in organ allografts have demonstrated that murine anti-CD3 mAbs are immunosuppressive. By mimicking Ag, anti-CD3 can produce T cell activation, anergy, or death. Activation of resting T cells in vivo results in dose-limiting cytokine release and is caused by Ab-mediated cross-linking of T cells and Fcgamma receptor (FcR)-bearing cells. With the goal of minimizing cytokine-induced toxicity, anti-CD3 have been engineered to lower Fc binding avidity. Preclinical murine studies have… CONTINUE READING