Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density.

@article{Barrs2009NonCpGMO,
  title={Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density.},
  author={Romain Barr{\`e}s and Megan E. Osler and Jie Yan and Anna Rune and Tomas Fritz and Kenneth Caidahl and Anna Krook and Juleen R Zierath},
  journal={Cell metabolism},
  year={2009},
  volume={10 3},
  pages={
          189-98
        }
}
Epigenetic modification through DNA methylation is implicated in metabolic disease. Using whole-genome promoter methylation analysis of skeletal muscle from normal glucose-tolerant and type 2 diabetic subjects, we identified cytosine hypermethylation of peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator-1 alpha (PGC-1alpha) in diabetic subjects. Methylation levels were negatively correlated with PGC-1alpha mRNA and mitochondrial DNA (mtDNA). Bisulfite sequencing revealed… CONTINUE READING

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