Non-Celiac Gluten Sensitivity: Literature Review

@article{Mansueto2014NonCeliacGS,
  title={Non-Celiac Gluten Sensitivity: Literature Review},
  author={Pasquale Mansueto and Aurelio Seidita and Alberto D’alcamo and Antonio Carroccio},
  journal={Journal of the American College of Nutrition},
  year={2014},
  volume={33},
  pages={39 - 54}
}
Background: A significant percentage of the general population report problems caused by wheat and/or gluten ingestion, even though they do not have celiac disease (CD) or wheat allergy (WA), because they test negative both for CD-specific serology and histopathology and for immunoglobulin E (IgE)-mediated assays. Most patients report both gastrointestinal and nongastrointestinal symptoms, and all report improvement of symptoms on a gluten-free diet. This clinical condition has been named non… 

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...

References

SHOWING 1-10 OF 139 REFERENCES

Cutting-Edge Issues in Celiac Disease and in Gluten Intolerance

TLDR
Some relevant aspects related to the laboratory diagnosis of CD and, more extensively, of gluten intolerance are considered, such as the best combination of tests for early and accurate diagnosis, the diagnostic role of new tests for detecting antibodies against neoepitopes produced by the transglutaminase–gliadin complex, the forms of non-celiac gluten intolerance (gluten sensitivity), and the use and significance of measuring cytokines in CD.

Non-Celiac Wheat Sensitivity Diagnosed by Double-Blind Placebo-Controlled Challenge: Exploring a New Clinical Entity

TLDR
The existence of non-celiac wheat sensitivity is demonstrated and the existence of two distinct populations of subjects with WS are suggested: one with characteristics more similar to CD and the other with characteristics pointing to food allergy.

Against the grain: An overview of celiac disease

  • Suzanne Martin
  • Medicine
    Journal of the American Academy of Nurse Practitioners
  • 2008
TLDR
Clinicians need to be cognizant of risk factors, clinical manifestations, conditions, and complications associated with CD in order to make a timely diagnosis, ameliorate symptoms, and minimize disease complications.

Emerging concepts: from coeliac disease to non-coeliac gluten sensitivity

TLDR
The historical relationship between mankind and gluten as well as the progressive recognition that it is possible for gluten to have a deleterious effect on the authors' health are reviewed.

Spectrum of gluten-related disorders: consensus on new nomenclature and classification

TLDR
This review will summarize the current knowledge about the three main forms of gluten reactions: allergic (wheat allergy), autoimmune (celiac disease, dermatitis herpetiformis and gluten ataxia) and possibly immune-mediated (gluten sensitivity), and also outline pathogenic, clinical and epidemiological differences and propose new nomenclature and classifications.

Serological Tests in Gluten Sensitivity (Nonceliac Gluten Intolerance)

TLDR
The serological pattern of GS is characterized by IgG AGA positivity in more than half of cases associated to IgA AGA in a few patients, but without EmA, tTGA, and DGP-AGA, which are the specific markers of celiac disease.

Nonceliac Gluten Sensitivity: Sense or Sensibility?

TLDR
If nonceliac gluten sensitivity is an etiologically heterogeneous syndrome, then management options should vary according to the predominant or concomitant underlying pathogenic pathways.

Neurologic and Psychiatric Manifestations of Celiac Disease and Gluten Sensitivity

TLDR
This review focuses on neurologic and psychiatric manifestations implicated with gluten sensitivity, reviews the emergence of gluten sensitivity distinct from celiac disease, and summarizes the potential mechanisms related to this immune reaction.

New understanding of gluten sensitivity

TLDR
Patients complain of IBS-like symptoms and extraintestinal manifestations that occur shortly after the ingestion of gluten, and symptoms improve or disappear when gluten is withdrawn from the diet, and recur if gluten is reintroduced.

Intolerance to cereals is not specific for coeliac disease.

TLDR
Intolerance to cereals is not a specific sign of overt or latent coeliac disease, and all experimental dietary interventions before proper diagnosis of coeliak disease are to be discouraged.
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