Non-Canonical Notch Signaling in Cancer and Immunity

@inproceedings{Ayaz2014NonCanonicalNS,
  title={Non-Canonical Notch Signaling in Cancer and Immunity},
  author={Furkan Ayaz and Barbara A Osborne},
  booktitle={Front. Oncol.},
  year={2014}
}
Canonical Notch signaling is initiated by γ-secretase-mediated cleavage of the Notch receptor, leading to the release of the active intra-cellular domain of Notch that migrates to the nucleus and interacts with RBP-Jκ, resulting in the activation of downstream target genes. While canonical Notch signaling is well known to play an active role in several steps during development as well in multiple cell fate decisions, recent evidence from both invertebrate and vertebrate systems indicates that… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
30 Extracted Citations
67 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 30 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 67 references

Similar Papers

Loading similar papers…