Non-Canonical Notch Signaling in Cancer and Immunity

  title={Non-Canonical Notch Signaling in Cancer and Immunity},
  author={Furkan Ayaz and Barbara A Osborne},
  booktitle={Front. Oncol.},
Canonical Notch signaling is initiated by γ-secretase-mediated cleavage of the Notch receptor, leading to the release of the active intra-cellular domain of Notch that migrates to the nucleus and interacts with RBP-Jκ, resulting in the activation of downstream target genes. While canonical Notch signaling is well known to play an active role in several steps during development as well in multiple cell fate decisions, recent evidence from both invertebrate and vertebrate systems indicates that… CONTINUE READING
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