Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4+ T Cells

@inproceedings{Dongre2014NonCanonicalNS,
  title={Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4+ T Cells},
  author={Anushka Dongre and Lalitha Surampudi and Rebecca G. Lawlor and Abdul H. Fauq and Lucio Miele and Todd E Golde and Lisa M Minter and Barbara A Osborne},
  booktitle={Front. Immunol.},
  year={2014}
}
Cleavage of the Notch receptor via a γ-secretase, results in the release of the active intra-cellular domain of Notch that migrates to the nucleus and interacts with RBP-Jκ, resulting in the activation of downstream target genes. This canonical Notch signaling pathway has been documented to influence T cell development and function. However, the mechanistic details underlying this process remain obscure. In addition to RBP-Jκ, the intra-cellular domain of Notch also interacts with other… CONTINUE READING
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