Non-ATP competitive protein kinase inhibitors.

@article{Garuti2010NonATPCP,
  title={Non-ATP competitive protein kinase inhibitors.},
  author={Laura Garuti and Marinella Roberti and Giovanni Bottegoni},
  journal={Current medicinal chemistry},
  year={2010},
  volume={17 25},
  pages={
          2804-21
        }
}
Protein kinases represent an attractive target in oncology drug discovery. Most of kinase inhibitors are ATP-competitive and are called type I inhibitors. The ATP-binding pocket is highly conserved among members of the kinase family and it is difficult to find selective agents. Moreover, the ATP-competitive inhibitors must compete with high intracellular ATP levels leading to a discrepancy between IC50s measured by biochemical versus cellular assays. The non-ATP competitive inhibitors, called… CONTINUE READING
42 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

Similar Papers

Loading similar papers…