Non–coding RNA genes and the modern RNA world

  title={Non–coding RNA genes and the modern RNA world},
  author={Sean R. Eddy},
  journal={Nature Reviews Genetics},
  • S. Eddy
  • Published 1 December 2001
  • Biology
  • Nature Reviews Genetics
Non-coding RNA (ncRNA) genes produce functional RNA molecules rather than encoding proteins. However, almost all means of gene identification assume that genes encode proteins, so even in the era of complete genome sequences, ncRNA genes have been effectively invisible. Recently, several different systematic screens have identified a surprisingly large number of new ncRNA genes. Non-coding RNAs seem to be particularly abundant in roles that require highly specific nucleic acid recognition… 

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Non-coding RNAs are defined as all functional RNA transcripts other than protein encoding messenger RNAs (mRNA), a unusual way of defining ncRNAs that reflects a historical bias in biology.

Non-Coding RNAs and their Integrated Networks

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Noncoding RNA transcripts.

Along with transfer RNAs, ribosomal RNAs and mRNAs, ncRNAs contribute to gene splicing, nucleotide modification, protein transport and regulation of gene expression, as well as regulate diverse cellular functions, including RNA processing, mRNA stability, translation, protein stability and secretion.

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The non-protein-coding transcriptional output of the cell is far greater than previously thought and common features of these RNAs provide clues about the evolutionary constraints that led to the development of RNA-guided proteins and the specific biological environments in which target specificity and diversity are most crucial to the cell.

RNomics: identification and function of small non-protein-coding RNAs in model organisms.

  • A. Hüttenhofer
  • Biology
    Cold Spring Harbor symposia on quantitative biology
  • 2006
Future challenges in the field of RNomics will include elucidation of their biological roles in the cell, in which many of these ncRNAs appear to function in guiding specific protein complexes to target nucleic acids.



Noncoding RNA genes.

  • S. Eddy
  • Biology
    Current opinion in genetics & development
  • 1999

Novel small RNA-encoding genes in the intergenic regions of Escherichia coli

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The 25-nucleotide antisense RNA detected in transgene-induced PTGS is likely synthesized from an RNA template and may represent the specificity determinant of PTGS.

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Small nucleolar RNA‐guided post‐transcriptional modification of cellular RNAs

  • T. Kiss
  • Biology, Chemistry
    The EMBO journal
  • 2001
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The non-coding RNAs as riboregulators

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Identification of novel small RNAs using comparative genomics and microarrays.

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  • W. Filipowicz
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2000
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