Non–AIDS-Defining Cancer Mortality: Emerging Patterns in the Late HAART Era

  title={Non–AIDS-Defining Cancer Mortality: Emerging Patterns in the Late HAART Era},
  author={Antonella Zucchetto and Saverio Virdone and Martina Taborelli and Enrico Grande and Laura Camoni and Marilena Pappagallo and Vincenza R{\`e}gine and Francesco Grippo and Jerry Polesel and Luigino Dal Maso and Barbara Suligoi and Luisa Frova and Diego Serraino},
  journal={JAIDS Journal of Acquired Immune Deficiency Syndromes},
Background:Non–AIDS-defining cancers (non-ADCs) have become the leading non-AIDS-related cause of death among people with HIV/AIDS. We aimed to quantify the excess risk of cancer-related deaths among Italian people with AIDS (PWA), as compared with people without AIDS (non-PWA). Methods:A nationwide, population-based, retrospective cohort study was carried out among 5285 Italian PWA, aged 15–74 years, diagnosed between 2006 and 2011. Date of death and multiple-cause-of-death data were retrieved… 

Incidence and mortality of non-AIDS-de fi ning cancers among people living with HIV: A systematic review and meta-analysis

The increased SIRs for various NADCs were more evident among PLHIV with advanced immunodeficiency, was explored by HIV transmission route, and use of HAART.

Increased kidney disease mortality among people with AIDS versus the general population: a population-based cohort study in Italy, 2006–2018

The excess mortality related to non-cancer kidney and other urinary tract diseases reported among PWA highlights the importance of implementing the recommendation for screening, diagnosis and management of such conditions among this population.

Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis

Findings of increased mortality and decreased survival among those with ADI (vs. without) were consistent for all other cancers, suggesting the need for further investigations into the role of HIV-related immune suppression and cancer outcomes.

Excess mortality related to circulatory system diseases and diabetes mellitus among Italian AIDS patients vs. non-AIDS population: a population-based cohort study using the multiple causes-of-death approach

The use of MCoD data disclosed the fairly high mortality excess related to several CSDs and DM among Italian PWA as compared to non-PWA, indicating to start preventive strategies for such diseases at a younger age among AIDS patients than in the general population and with focus on drug users.

The Management of HIV-Hodgkin Lymphoma

Since 1996, the availability of highly active antiretroviral therapy (HAART) has led to improvements in immune status among HIV-infected persons, reducing AIDS-related morbidity and prolonging

Factors associated with non-AIDS-defining cancers and non HCV-liver related cancers in HIV/HCV-coinfected patients- ANRS-CO13 HEPAVIH cohort

Age and the duration of HIV infection were the only characteristics found to be associated with the occurrence of NANL related cancer among HIV/HCV-coinfected patients, and no association was observed with any HCV-related variables.

Factors associated with non-AIDS-defining cancers and non HCV-liver related cancers in HIV / HCV-coinfected patients-ANRS-CO 13 HEPAVIH cohort

Age and the duration of HIV infection were the only characteristics found to be associated with the occurrence of NANL related cancer among HIV/HCV-coinfected patients, and no association was observed with any HCV-related variables.



Non-AIDS defining cancers in the D:A:D Study - time trends and predictors of survival: a cohort study

The prognosis after diagnosis of NADC, in particular lung cancer and disseminated cancer, is poor but has improved somewhat over time, and modifiable risk factors, such as smoking and low CD4 counts, were associated with mortality following a diagnosis.

Survival After Cancer in Italian Persons With AIDS, 1986–2005: A Population-Based Estimation

The persisting, although narrowing, gap in cancer survival between PWA and non-PWA indicates the necessity of enhancing therapeutic approaches, so that PWA can be provided the same chances of survival observed in the general population, and improving cancer prevention and screening.

Cancer incidence and mortality for all causes in HIV-infected patients over a quarter century: a multicentre cohort study

In HIV infected patients, ADC but not NADC incidence rates were higher than the general population, and although overall mortality in HIV infected subjects decreased over time, it is about three-fold higher thanThe general population at present.

Risk factors for early mortality after AIDS in the cART era: A population-based cohort study in Italy

Among Italian PWA, the high- though slightly decreasing - frequency of early mortality in the full cART era is documented, indicating the need for enduring and ameliorating preventive actions aimed at timely HIV testing among all individuals at risk for HIV infection and/or those who present diseases known to be related with HIV infection.

Cancer-Related Causes of Death among HIV-Infected Patients in France in 2010: Evolution since 2000

Cancer prevention (especially smoking cessation), screening strategies and therapeutic management need to be optimized in HIV-infected patients in order to reduce mortality, particularly in the field of respiratory cancers.

Pattern of cancer risk in persons with AIDS in Italy in the HAART era

The excess of some potentially preventable cancers in PWHA suggests that HAART use must be accompanied by cancer-prevention strategies, notably antismoking and cervical cancer screening programmes, as well as improvements in the timely identification of HIV-positive individuals.

Causes of death in HIV-1-infected patients treated with antiretroviral therapy, 1996-2006: collaborative analysis of 13 HIV cohort studies.

  • J. GillM. May J. Sterne
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2010
Rates of each cause of death were higher in patients with presumed transmission via injection drug use than in other patients, with marked increases in rates of liver-related and respiratory tract-related mortality.

Survival in HIV-Infected Patients after a Cancer Diagnosis in the cART Era: Results of an Italian Multicenter Study

Objectives We studied survival and associated risk factors in an Italian nationwide cohort of HIV-infected individuals after an AIDS-defining cancer (ADC) or non-AIDS-defining cancer (NADC) diagnosis

Elevated Cancer-Specific Mortality Among HIV-Infected Patients in the United States.

HIV-infected patients with cancer experienced higher cancer-specific mortality than HIV-un Infected patients, independent of cancer stage or receipt of cancer treatment, according to a comprehensively evaluated study.

Causes of death among Danish HIV patients compared with population controls in the period 1995–2008

After the introduction of highly active antiretroviral therapy (HAART), the AIDS-related mortality has decreased substantially, but the long-term exposure to HIV and HAART has not translated into increasing mortality from malignancy, cardiovascular, and hepatic diseases.