Non‐catalytic tyrosine‐phosphorylated receptors

@article{Dushek2012NoncatalyticTR,
  title={Non‐catalytic tyrosine‐phosphorylated receptors},
  author={Omer Dushek and J. Goyette and P. A. Merwe},
  journal={Immunological Reviews},
  year={2012},
  volume={250},
  pages={258 - 276}
}
Leukocytes play a critical role in recognizing and responding to infection and cancer. Central to this function is an array of cell‐surface receptors that lack sequence homology. Many of these receptors have in common the fact that their signaling involves phosphorylation of cytoplasmic domains by extrinsic tyrosine kinases. These non‐catalytic tyrosine‐phosphorylated receptors (NTRs) share a number of other features, including small size and optimal stimulation by surface–associated ligands… Expand
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References

SHOWING 1-10 OF 115 REFERENCES
A mechanism for SRC kinase-dependent signaling by noncatalytic receptors.
  • 42
  • Highly Influential
Cell Signaling by Receptor Tyrosine Kinases
  • 3,109
  • PDF
CD45: a critical regulator of signaling thresholds in immune cells.
  • 720
  • Highly Influential
The Janus kinase family of protein tyrosine kinases and their role in signaling
  • 131
CLEC-2 activates Syk through dimerization.
  • 129
  • PDF
CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells
  • 152
  • Highly Influential
Regulation of Src Family Kinases Involved in T Cell Receptor Signaling by Protein-tyrosine Phosphatase CD148*
  • 32
  • PDF
Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling
  • 99
  • PDF
A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation.
  • 194
  • PDF
...
1
2
3
4
5
...