NompC TRP Channel Required for Vertebrate Sensory Hair Cell Mechanotransduction

@article{Sidi2003NompCTC,
  title={NompC TRP Channel Required for Vertebrate Sensory Hair Cell Mechanotransduction},
  author={Samuel Sidi and Rainer W. Friedrich and Teresa Nicolson},
  journal={Science},
  year={2003},
  volume={301},
  pages={96 - 99}
}
The senses of hearing and balance in vertebrates rely on the sensory hair cells (HCs) of the inner ear. The central element of the HC's transduction apparatus is a mechanically gated ion channel of unknown identity. Here we report that the zebrafish ortholog of Drosophila no mechanoreceptor potential C (nompC), which encodes a transient receptor potential (TRP) channel, is critical for HC mechanotransduction. In zebrafish larvae, nompC is selectively expressed in sensory HCs. Morpholino… 
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