Nomifensine: A Review of its Pharmacological Properties and Therapeutic Efficacy in Depressive Illness

@article{Brogden2012NomifensineAR,
  title={Nomifensine: A Review of its Pharmacological Properties and Therapeutic Efficacy in Depressive Illness},
  author={Rex N. Brogden and Rennie C. Heel and Trevor M. Speight and Graeme S. Avery},
  journal={Drugs},
  year={2012},
  volume={18},
  pages={1-24}
}
SummarySynopsis: Nomifensine1 is a tetrahydroisoquinoline antidepressant which is chemically unrelated to the tricyclic or tetracyclic antidepressants, the monoamine oxidase inhibitors or the recently introduced agents. Nomifensine resembles the tricyclic antidepressants in many of its pharmacological effects in animal models of depressive illness, but differs from them in that it strongly inhibits the re-uptake of dopamine as well as noradrenaline and is a relatively weak inhibitor of… 
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