Nomegestrol Acetate/Estradiol

@article{Yang2012NomegestrolA,
  title={Nomegestrol Acetate/Estradiol},
  author={Lily P. H. Yang and Greg L. Plosker},
  journal={Drugs},
  year={2012},
  volume={72},
  pages={1917-1928}
}
Nomegestrol acetate/estradiol is a combined oral contraceptive with approval in many countries. This fixed-dose combination tablet contains nomegestrol acetate, a highly selective progestogen, and estradiol, a natural estrogen. It is the first monophasic combined oral contraceptive to contain estradiol, and is taken in 28-day cycles, consisting of 24 active therapy days with 4 placebo days (i.e. 24/4-day cycles).In two large, 1-year, randomized, open-label, multicentre, phase III trials in… Expand
Nomegestrol acetate/estradiol: a guide to its use in oral contraception
TLDR
Nomegestrol acetate/estradiol (Zoely™) is the first monophasic combined oral contraceptive to contain estradiol and was at least as effective (in terms of the Pearl Index) as drospirenone/ethinylESTradiol. Expand
The Effect of Therapeutic and Supratherapeutic Oral Doses of Nomegestrol Acetate (NOMAC)/17β-Estradiol (E2) on QTcF Intervals in Healthy Women: Results from a Randomized, Double-Blind, Placebo- and Positive-Controlled Trial
TLDR
This thorough QT/QTc study showed that therapeutic and supratherapeutic doses of NOMAC/E2 were not associated with clinically relevant QTc interval prolongation in healthy women after a 2-week period of dosing. Expand
Effect of oral contraceptives containing estradiol and nomegestrol acetate or ethinyl-estradiol and chlormadinone acetate on primary dysmenorrhea
TLDR
Both oral contraceptives reduced similarly primary dysmenorrhea, with E2/NOMAC also reducing withdrawal bleedings and being neutral on lipid metabolism. Expand
Pharmacokinetics, tissue distribution, and excretion of nomegestrol acetate in female rats
TLDR
NOMAC had a widespread distribution in tissues, including ovary, pituitary, and hypothalamus, which are main target tissues where NOMAC inhibits ovulation, and enteredohepatic circulation was found in the drug elimination. Expand
Prediction of nomegestrol acetate pharmacokinetics in healthy female adolescents and adults by whole-body physiology-based pharmacokinetic modelling and clinical validation.
TLDR
The whole-body physiology-based model described here complements classic noncompartmental and population PK approaches and has the ability to expand to adolescent postmenarcheal adolescent population data and applying physiological scaling. Expand
An Improved Synthesis of Nomegestrol Acetate
Oral contraceptives (OCs) are synthetic steroids, or progestins, which are structurally related to testosterone or to progesterone. Many progestins have been synthesized and approved for OCs,Expand
Isolation, synthesis, and cytotoxicity evaluation of two impurities in nomegestrol acetate
TLDR
Both impurities and NOMAc were evaluated for their in vitro cytotoxicities against L02 liver cells, mesenchymal stem cells, MCF‐7 breast cancer cells, and C33A cervical cancer cells and impurity B did not show significant cytotoxicity to any of the cell lines tested. Expand
Combined hormonal influence of cyproterone acetate and nomegestrol acetate on meningioma: a case report
TLDR
The use of Nomegestrol acetate as replacement for CPA in the presence of a meningioma should be discouraged until further evidence becomes available on the role of NOMAC. Expand
Spontaneous regression of meningiomas after interruption of nomegestrol acetate: a series of three patients
TLDR
The first cases of meningiomas responsiveness to discontinuation of hormonal therapy with NOMAC are reported, similar to cases associated with long-term CPA intake, tumor reduction, and improvement of clinical symptoms can be observed after cessation of NOMac. Expand
Modeling the Photocatalytic Mineralization in Water of Commercial Formulation of Estrogens 17-β Estradiol (E2) and Nomegestrol Acetate in Contraceptive Pills in a Solar Powered Compound Parabolic Collector
TLDR
The optimum removal of the estrogens and TOC was achieved at a catalyst concentration of 0.4 g/L in 29 mm diameter tubular CPC reactors which approached the optimum catalyst concentration and optical thickness determined from the modeling of the absorption of solar radiation in the CPC, by the six-flux absorption-scattering model (SFM). Expand
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TLDR
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