Noladin ether, a putative novel endocannabinoid: inactivation mechanisms and a sensitive method for its quantification in rat tissues

@article{Fezza2002NoladinEA,
  title={Noladin ether, a putative novel endocannabinoid: inactivation mechanisms and a sensitive method for its quantification in rat tissues},
  author={F. Fezza and T. Bisogno and A. Minassi and G. Appendino and R. Mechoulam and V. Di Marzo},
  journal={FEBS Letters},
  year={2002},
  volume={513}
}
The occurrence of the novel proposed endocannabinoid, noladin ether (2‐arachidonyl glyceryl ether, 2‐AGE) in various rat organs and brain regions, and its inactivation by intact C6 glioma cells, were studied. 2‐AGE was measured by isotope dilution liquid chromatography‐atmospheric pressure chemical ionization‐mass spectrometry, with a detection limit of 100 fmol. A compound with the same mass and chromatographic/chemical properties as 2‐AGE was found in whole brain, with the highest amounts in… Expand
127 Citations
The endocannabinoid system: a general view and latest additions
  • 451
  • Highly Influenced
A simple LC-MS/MS method for the simultaneous quantification of endocannabinoids in biological samples.
Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoid.
  • 47
  • PDF
Determination of endocannabinoids in nematodes and human brain tissue by liquid chromatography electrospray ionization tandem mass spectrometry.
  • 45
The Endocannabinoid Noladin Ether Acts as a Full Agonist at Human CB2 Cannabinoid Receptors
  • 71
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 26 REFERENCES
Brain regional distribution of endocannabinoids: implications for their biosynthesis and biological function.
  • 287
2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor
  • 743
  • PDF
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.
  • 2,512
Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells.
  • 193
  • PDF
The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors.
  • 157
2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain.
  • 1,897
...
1
2
3
...