Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay

@article{Zhang2009NoisySM,
  title={Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay},
  author={Zhenguo Zhang and Dedong Xin and Ping Wang and Li Zhou and Lan-Dian Hu and Xiangyin Kong and Laurence D Hurst},
  journal={BMC Biology},
  year={2009},
  volume={7},
  pages={23 - 23}
}
Nonsense-mediated decay is a mechanism that degrades mRNAs with a premature termination codon. That some exons have premature termination codons at fixation is paradoxical: why make a transcript if it is only to be destroyed? One model supposes that splicing is inherently noisy and spurious transcripts are common. The evolution of a premature termination codon in a regularly made unwanted transcript can be a means to prevent costly translation. Alternatively, nonsense-mediated decay can be… CONTINUE READING