Noise stress impairs prefrontal cortical cognitive function in monkeys: evidence for a hyperdopaminergic mechanism.

@article{Arnsten1998NoiseSI,
  title={Noise stress impairs prefrontal cortical cognitive function in monkeys: evidence for a hyperdopaminergic mechanism.},
  author={Amy F T Arnsten and Patricia S. Goldman-Rakic},
  journal={Archives of general psychiatry},
  year={1998},
  volume={55 4},
  pages={
          362-8
        }
}
BACKGROUND Stress can exacerbate a number of psychiatric disorders, many of which are associated with prefrontal cortical (PFC) cognitive deficits. Biochemical studies demonstrate that mild stress preferentially increases dopamine turnover in the PFC. Our study examined the effects of acute, mild stress exposure on higher cognitive function in monkeys and the role of dopaminergic mechanisms in the stress response. METHODS The effects of loud (105-dB) noise stress were examined on a spatial… CONTINUE READING

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