Noise in gene expression determines cell fate in Bacillus subtilis.

@article{Maamar2007NoiseIG,
  title={Noise in gene expression determines cell fate in Bacillus subtilis.},
  author={H{\'e}dia Maamar and Arjun Raj and David Dubnau},
  journal={Science},
  year={2007},
  volume={317 5837},
  pages={
          526-9
        }
}
Random cell-to-cell variations in gene expression within an isogenic population can lead to transitions between alternative states of gene expression. Little is known about how these variations (noise) in natural systems affect such transitions. In Bacillus subtilis, noise in ComK, the protein that regulates competence for DNA uptake, is thought to cause cells to transition to the competent state in which genes encoding DNA uptake proteins are expressed. We demonstrate that noise in comK… CONTINUE READING

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