Noise Propagation and Signaling Sensitivity in Biological Networks: A Role for Positive Feedback

@article{Hornung2008NoisePA,
  title={Noise Propagation and Signaling Sensitivity in Biological Networks: A Role for Positive Feedback},
  author={Gil Hornung and Naama Barkai},
  journal={PLoS Computational Biology},
  year={2008},
  volume={4},
  pages={10040 - 10045}
}
Interactions between genes and proteins are crucial for efficient processing of internal or external signals, but this connectivity also amplifies stochastic fluctuations by propagating noise between components. Linear (unbranched) cascades were shown to exhibit an interplay between the sensitivity to changes in input signals and the ability to buffer noise… CONTINUE READING