Noise-Induced Mechanism for Biological Homochirality of Early Life Self-Replicators.

@article{Jafarpour2015NoiseInducedMF,
  title={Noise-Induced Mechanism for Biological Homochirality of Early Life Self-Replicators.},
  author={Farshid Jafarpour and Tommaso Biancalani and Nigel Goldenfeld},
  journal={Physical review letters},
  year={2015},
  volume={115 15},
  pages={
          158101
        }
}
The observed single-handedness of biological amino acids and sugars has long been attributed to autocatalysis. However, the stability of homochiral states in deterministic autocatalytic systems relies on cross inhibition of the two chiral states, an unlikely scenario for early life self-replicators. Here, we present a theory for a stochastic individual-level model of autocatalysis due to early life self-replicators. Without chiral inhibition, the racemic state is the global attractor of the… 

Figures from this paper

Noise-induced symmetry breaking far from equilibrium and the emergence of biological homochirality.
TLDR
It is concluded that nonequilibrium autocatalysis is a viable mechanism for homochirality, without imposing additional nonlinearities such as chiral inhibition.
Necessary conditions for the emergence of homochirality via autocatalytic self-replication.
TLDR
The stability of the thermodynamic limit proves that the racemic outcome is the unique stable state for strictly irreversible externally driven autocatalysis, contradict the suggestion that the inhibition requirement of the Frank autoc atalytic model for the emergence of homochirality may be relaxed in a noise-induced mechanism.
Chiral autocatalysis: reaction noise, micro-reversibility and chiral inhibition in mirror symmetry breaking
TLDR
The findings suggest that first-order autocatalysis coupled to reactions involving \textit{non-linear} heterochiral dynamics is a necessary pre-condition for any mechanism purporting to lead to molecular homochirality.
Autocatalytic Models for the Origin of Biological Homochirality.
TLDR
The history of the theoretical models and the experimental work that led up to the discovery of the remarkable, singular Soai reaction are traced.
Energy threshold for chiral symmetry breaking in molecular self-replication
TLDR
The magnitude of the energy imbalance required to induce directed symmetry breaking and asymmetric amplification in the Soai reaction has now been identified and compared to the parity violation energy difference.
Emergence of homochirality in large molecular systems
TLDR
It is shown that large molecular systems are likely to undergo a phase transition toward a homochiral state, as a consequence of the fact that they contain a large number of chiral species.
The Limited Roles of Autocatalysis and Enantiomeric Cross-Inhibition in Achieving Homochirality in Dilute Systems
  • A. Brandenburg
  • Chemistry
    Origins of Life and Evolution of Biospheres
  • 2019
To understand the effects of fluctuations on achieving homochirality, we employ a Monte-Carlo method where autocatalysis and enantiomeric cross-inhibition, as well as racemization and deracemization
Self-Reproduction and Darwinian Evolution in Autocatalytic Chemical Reaction Systems
TLDR
This review starts by evaluating theoretical studies of ACSs specifically with a view to establish the conditions required for such chemical systems to exhibit self-reproduction and Darwinian evolution, and follows with an extensive overview of experimental ACS systems.
Universal biology and the statistical mechanics of early life
TLDR
This article describes recent efforts to provide a narrative of this epoch using tools from statistical mechanics, and shows how this phase ultimately terminated during an event sometimes known as the Darwinian transition, leading to the present epoch of tree-like vertical descent of organismal lineages.
...
...

References

SHOWING 1-10 OF 57 REFERENCES
Stochastic processes in physics and chemistry
Preface to the first edition. Preface to the second edition. Abbreviated references. I. Stochastic variables. II. Random events. III. Stochastic processes. IV. Markov processes. V. The master
Nature
  • R. Rosenfeld
  • Medicine
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • 2009
- int
  • Medicine
  • 2004
TLDR
The cooperation with leading scientists from all fields of research and higher education and ministers for research in Germany and the experience of giving expert advice to the federal and the state governments in Germany were very interesting experiences.
Biochim
  • Biophys. Acta 11, 459
  • 1953
Bull
  • Math. Biol. 76, 895
  • 2014
Origins Life Evol
  • Biosphere 33, 575
  • 2003
In the original model by Frank, the concentration of the
  • In the original model by Frank, the concentration of the
...
...