Noise-Driven Stem Cell and Progenitor Population Dynamics

  title={Noise-Driven Stem Cell and Progenitor Population Dynamics},
  author={Martin Hoffmann and Hannah H. Chang and Sui Huang and Donald E. Ingber and Markus L{\"o}ffler and Joerg Galle},
  journal={PLoS ONE},
  pages={574 - 578}
BACKGROUND The balance between maintenance of the stem cell state and terminal differentiation is influenced by the cellular environment. The switching between these states has long been understood as a transition between attractor states of a molecular network. Herein, stochastic fluctuations are either suppressed or can trigger the transition, but they do… CONTINUE READING