Noise-Driven Causal Inference in Biomolecular Networks

  title={Noise-Driven Causal Inference in Biomolecular Networks},
  author={Robert J. Prill and Robert Vogel and Guillermo A. Cecchi and Gr{\'e}goire Altan-Bonnet and Gustavo Stolovitzky and Alberto de la Fuente},
  booktitle={PloS one},
Single-cell RNA and protein concentrations dynamically fluctuate because of stochastic ("noisy") regulation. Consequently, biological signaling and genetic networks not only translate stimuli with functional response but also random fluctuations. Intuitively, this feature manifests as the accumulation of fluctuations from the network source to the target… CONTINUE READING