Nogo signaling and non-physical injury-induced nervous system pathology.

  title={Nogo signaling and non-physical injury-induced nervous system pathology.},
  author={Felicia Yu Hsuan Teng and Bor Luen Tang},
  journal={Journal of neuroscience research},
  volume={79 3},
The Nogo gene products were described first as myelin-associated inhibitors that prevent neuronal regeneration upon injury. Recent findings have also implicated Nogo in several neuronal pathologies that are not induced by physical injury. Nogo-A may be an important determinant of autoimmune demyelinating diseases, as active immunization with Nogo-A fragments attenuates the symptoms of experimental autoimmune encephalomyelitis (EAE). Nogo-A levels are elevated markedly in hippocampal neurons of… CONTINUE READING


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