Nogo-receptor gene activity: cellular localization and developmental regulation of mRNA in mice and humans.

@article{Josephson2002NogoreceptorGA,
  title={Nogo-receptor gene activity: cellular localization and developmental regulation of mRNA in mice and humans.},
  author={Anna Josephson and Alexandra Trifunovski and Hans Ruedi Widmer and Johan Widenfalk and Lars Olson and Christian Spenger},
  journal={The Journal of comparative neurology},
  year={2002},
  volume={453 3},
  pages={292-304}
}
Nogo (reticulon-4) is a myelin-associated protein that is expressed in three different splice variants, Nogo-A, Nogo-B, and Nogo-C. Nogo-A inhibits neurite regeneration in the central nervous system. Messenger RNA encoding Nogo is expressed in oligodendrocytes and central and peripheral neurons, but not in astrocytes or Schwann cells. Nogo is a transmembraneous protein; the extracellular domain is termed Nogo-66, and a Nogo-66-receptor (Nogo-R) has been identified. We performed in situ… CONTINUE READING

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