Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity.

  title={Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity.},
  author={Jae-Hyun Lee and Ji-Eun Kim and Michael Sivula and Stephen M Strittmatter},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={24 27},
After ischemic stroke, partial recovery of function frequently occurs and may depend on the plasticity of axonal connections. Here, we examine whether blockade of the Nogo-NogoReceptor (NgR) pathway might enhance axonal sprouting and thereby recovery after focal brain infarction. Mutant mice lacking NgR or Nogo-AB recover complex motor function after stroke more completely than do control animals. After a stroke, greater numbers of axons emanating from the undamaged cortex cross the midline to… CONTINUE READING
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