Nogo and Nogo-66 receptor in human and chick: implications for development and regeneration.

@article{ONeill2004NogoAN,
  title={Nogo and Nogo-66 receptor in human and chick: implications for development and regeneration.},
  author={P. O'Neill and Katherine Whalley and Patrizia Ferretti},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2004},
  volume={231 1},
  pages={109-21}
}
Antibodies to the myelin protein Nogo increase axonal regrowth after central nervous system injury. We have investigated whether Nogo expression contributes to loss of regenerative potential during development by using chick embryos, which regenerate their spinal cord until embryonic day (E) 13, when myelination begins. We show that Nogo-A and the Nogo receptor (NgR) are developmentally regulated both in chick and human embryos, are first detected at developmental stages when the chick spinal… CONTINUE READING
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