Nogo-B receptor is essential for angiogenesis in zebrafish via Akt pathway.

@article{Zhao2010NogoBRI,
  title={Nogo-B receptor is essential for angiogenesis in zebrafish via Akt pathway.},
  author={Baofeng Zhao and Changzoon Chun and Zhong Liu and Mark A Horswill and Kallal Pramanik and George Albert Wilkinson and Ramani Ramchandran and Robert Qing Miao},
  journal={Blood},
  year={2010},
  volume={116 24},
  pages={5423-33}
}
Our previous work has shown that axon guidance gene family Nogo-B and its receptor (NgBR) are essential for chemotaxis and morphogenesis of endothelial cells in vitro. To investigate NogoB-NgBR function in vivo, we cloned the zebrafish ortholog of both genes and studied loss of function in vivo using morpholino antisense technology. Zebrafish ortholog of Nogo-B is expressed in somite while expression of zebrafish NgBR is localized in intersomitic vessel (ISV) and axial dorsal aorta during… CONTINUE READING

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